Multiple Sclerosis

Research Studies

Detection of Chlamydial Bodies and Antigens in the Central Nervous System of Patients with Multiple Sclerosis

n= 20 MS cases and 12 other Neurological Diseases (OND), The Journal of Infectious Diseases, 2005.
Methods- post-mortem brain tissue and CSF from MS and OND cases analyzed for the presence of Chlamydia pneumoniae using Immunohistochemistry (IHC), electron microscopy, and PCR.
Results- Chlamydia pneumonaie was confirmed via IHC, electron microscopy and PCR in a significant number of MS cases.
Conclusion- though this does not definitely prove causation between C. pneumoniae and MS, Chlamydial antigens may prove to be a trigger to MS leading to auto-immune involvement.

Infection with Chlamydia pneumoniae and risk of multiple sclerosis.

Nested, case-control analysis, n=62,548 women (141 with MS), Epidemiology, 2003.
Methods- serum samples assessed for Cpn-specific immunoglobulin G antibodies is MS cases versus two healthy, age-matched controls.
Results- Cpn IgG seropositivity was positively associated with risk of MS.  The association with relapsing-remitting MS was moderate while the association with progressive MS was strong.
Conclusion- These results prove a positive association between Cpn infection and progressive MS.

Review Papers

A Review of Multiple Sclerosis as an Infectious Syndrome

Role of Chlamydophila pneumoniae in the Pathogenesis of Chronic Cerebrospinal Venous Insuffiency in Patients with Multiple Sclerosis

Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae.

Dr. David Wheldon: Halting MS

Dr. Wheldon successfully treated his wife’s MS with antibiotics.  This video chronicles her treatment, the research that backs this treatment protocol and the barriers that exist in the medical community.  Cases like this demand attention and highlight a valid, long-overdue question:

How many MS cases are treatable with antibiotics?